Topic
Metabolic health
Insulin, glucose, lipids, GLP-1s.
Episodes
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Episode 1
GLP-1s, Bryan Johnson's routine, and whether NAD is worth your money
Four longevity doctors on what they've seen in four years of prescribing GLP-1s, why influencer protocols don't translate to patients, and the case for and against NAD.
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Episode 2
GLP-1 surprise pregnancies, female hormones, and sex after 40 for both of you
Why women on GLP-1s are getting pregnant, what nobody asks women about sex, how the four of us think about estradiol, progesterone and testosterone, and the parts of male sexual function a pill doesn't fix.
Articles
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Article
GLP-1 drugs, PCOS, and the fertility effect that needs a conversation
Weight loss can restore ovulation. Women on GLP-1s are conceiving without planning to. What the prescribing conversation has to cover.
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Article
Keto, fasting, and energy balance: positions that changed with the data
Metabolic ward studies on ketogenic and ultra-processed diets, the TREAT trial on time-restricted eating, a metformin trial in older adults, and what each one settled.
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Article
Gray-market peptides, retatrutide, and the difference between a drug and a vial
Retatrutide is unapproved, so every vial sold under that name is unregulated. What the testing shows, and what the evidence for most peptides looks like.
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Article
Lean mass loss on GLP-1 drugs, and the myostatin drugs trying to prevent it
A quarter to 40 percent of GLP-1 weight loss is lean mass on a DEXA scan. Myostatin blockers preserve it on the scan. So far they have not preserved strength.
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Article
GLP-1 medications beyond weight loss: how far do the benefits extend?
Heart, kidney, liver, sleep apnea, and two stranger findings. Which GLP-1 benefits are explained by weight loss, and which are not.